Cucurbit[7]uril‐Mediated Organ‐Specific Delivery of Ultrasmall NIR‐II Luminescent Gold Nanocarriers for Therapy of Acute Kidney Injury
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract The design of nanocarriers that selectively target the liver or kidney is a significant challenge in drug delivery due to the diverse physiological structures and inherent characteristics, as well as their distinct requirements for nanocarriers. Herein, a strategy to synthesize a series of second near‐infrared region (NIR‐II) emitting gold nanocarriers for fine‐tuning liver or kidney‐specific delivery via altering their surface chemistry using cucurbit[7]uril (CB[7]) and Cys‐Arg‐Gly‐Asp (CRGD) peptide is reported. Accordingly, it shows that ultrasmall nanocarriers can facilitate kidney‐targeted delivery in cisplatin‐induced acute kidney injury (AKI) mice, which significantly boosted the accumulation of dexamethasone (DXM) loaded onto the nanocarriers at the site of injured kidneys, thereby achieving improved therapeutic results. Thus, this organ‐specific delivery strategy holds tremendous promise for improving drug delivery efficiency and providing new perspectives and methods for personalized treatments.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it