S3275 Primary Signet Ring Cell Carcinoma Within Ileocolonic Crohn’s Disease Stricture
Bibliographic record
Abstract
Introduction: Inflammatory bowel disease (IBD) associated colorectal cancer (CRC) is associated with a significant portion of IBD mortality with studies demonstrating mortality rates in IBD-CRC patients between 10% to 15%. Signet ring cell carcinoma (SRCC) is a rare and devastating form of adenocarcinoma that makes up less than 1% of all CRC. While previous case reports have documented IBD with small intestine SRCC, here we present an abnormal case report of SRCC, arising from a tubular adenoma within chronic ileocolonic Crohn's disease (CD). Case Description/Methods: A 64-year-old woman with a long-standing history of stricturing ileocolonic CD (Montreal classification A3L3B2) who was maintained on vedolizumab infusion every 4 weeks, presented to our clinic with acute onset epigastric pain and nausea. Her physical exam did not elicit any specific signs of concern. Her vitals were otherwise stable. Labs performed showed elevated calprotectin of 725 µg/g but normal CBC, CMP, and c-reactive protein. Given her history of stenotic disease, she underwent a colonoscopy that demonstrated an intrinsic area of severe stenosis in the ascending colon. Multiple biopsies were taken of this stenotic region which ultimately demonstrated SRCC. Later, she underwent laparoscopic hemicolectomy with ileocolonic anastomosis. During surgery, no obvious mass was seen. The pathology later confirmed SRCC with local lymph node metastasis arising from a tubular adenoma in a background of chronic ileitis/colitis, consistent with her IBD history. After surgery, the patient preferred active surveillance compared to adjuvant chemotherapy. Ultimately, less than a year after surgery her CT scans show local recurrence and distant metastasis. Discussion: To our knowledge this is one of few documented cases of SRCC presenting within a background of active ileocolonic CD. Cases of simultaneous SRCC and CD have been reported, but no clear association has yet been established. Some risk factors include extent of inflammation, younger age at diagnosis, family history of CRC, and coexistence with primary sclerosing cholangitis. Notably, several recent studies show an overall risk reduction in the development of CRC in IBD, likely due to early diagnosis, frequent surveillance and advanced treatments reducing overall inflammation in these patients. With SRCC being a particularly aggressive form of CRC, we highlight the importance of prompt evaluation in uncontrolled CD patients and new colonic strictures.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".