Ferrocene‐Peptide Conjugate for the Detection and Quantification of Ascorbic Acid
Bibliographic record
Abstract
Abstract Ferrocene (Fc) is a widely used metallocene, with well‐characterized redox behaviour that is vastly used in a variety of applications. Ferrocene‐coupling to peptides renders the resulting bioorganometallic peptide conjugate redox active and sensitive to changes in the chemical environment. The disulfide‐linked ferrocene peptide conjugate (FcCO‐Phe‐Cys‐OH) 2 was synthesized and characterized by NMR, MS, and FT‐IR spectroscopies and then exploited for the detection of ascorbic acid. Here we demonstrate that the Cu(II) complex of this peptide conjugate allows the detection of ascorbic acid with a limit of detection of 0.02 μM with a linear range of 0.1–25 μM. This is the first report of the use of a peptide metal complex for direct modification of a glass carbon electrode and its application for ascorbic acid detection and quantification, including in commercial beverages. The modified GCE exhibited excellent selectivity, stability, and sensitivity.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".