A modular photoredox route towards sulfoximines
Why this work is in the frame
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Bibliographic record
Abstract
We report a modular photoredox strategy for the synthesis of aryl vinyl sulfoximines from sulfinamide and vinyl halide starting materials. This strategy demonstrates a difunctionalization of sulfinamides to sulfoximine products with excellent configurational retention and stereoselective trans alkenes. Under mild redox conditions, we propose the generation of a nitrogen centered radical that is resonance stabilized by a sulfur radical partner, increasing overall radical lifetime. This strategy we disclose is thus well suited for vinyl halide radical capture, leading to sulfoximine products. This process also entails broad modularity about the alkene, arene, and acyl protecting group, providing synthetic chemists multiple functional handles allowing for further exploration into the physicochemical properties that have shown promise in recent studies.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it