Lower respiratory tract involvement in recurrent respiratory papillomatosis in a multicentric cohort study
Bibliographic record
Abstract
Recurrent respiratory papillomatosis (RRP) is a rare disease due to chronic Human Papillomavirus infection, occurring in childhood (JoRRP) or in adults (AoRRP). PRR is characterized by a progressive obstruction by papillomas mostly affecting upper airway and more rarely lower respiratory tract (LRT), including lungs. This study describes the characteristics of Jo and AoRRP LRT at adulthood. French and Quebecers’ national retrospective study of the clinical, histological, therapeutic and prognostic characteristics with RRP-LRT. Among the 67 patients (pts), 17 (25%) were JoRRP and 50 (75%) AoRRP. The mean age at diagnosis was 5 yrs for JoRRP and 54 yrs for AoRRP. ENT involvement was observed in all JoRRP and in 23 (46%) AoRRP. Lung involvement was observed in 11 (76%) JoRRP and 2 (4%) AoRRP. Mean latency duration between ENT and lung involvement was 26 yrs in JoRRP and 4 yrs in AoRRP. Lung CT-scan findings were cysts in 11 pts (74%) and nodules/mass in 2 (13%), predominating in the lower lobes. 13 pts (19%) had malignant transformation to squamous cell carcinoma in the trachea (n=3) and the lung (n=10). Associated factors with lung involvement were female gender, JoRRP, HPV-11, repeated desobstruction and tracheostomy while they were JoRRP, HPV-16 and presence of ENT or lung involvements for malignant transformation. Overall mortality was 9%, JoRRP form, lung involvement and malignant transformation being prognostic factors (p<0.05). In this largest cohort of RRP LRT, the high frequency of lung involvement and malignant transformation, justify targeted screening measures and preventive therapeutic strategy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".