Manifestation of oculorenal syndrome in a dog chronically receiving zonisamide
Bibliographic record
Abstract
Abstract Tubulointerstitial nephropathy and uveitis, otherwise more broadly known as oculorenal syndrome in human medicine, is a condition that has, to the authors’ knowledge, not been described in veterinary medicine. This report describes an 8‐year‐old, male, neutered, mixed breed dog with a 6‐year history of idiopathic epilepsy, chronically receiving zonisamide, who was presented for sub‐acute and recurrent episodes of severe generalised weakness, altered mentation and inappropriate urination. Throughout the dog's hospital visits, recurrent anterior uveitis, progressive severe metabolic acidosis, proteinuria, persistent granular casts and severe renal tubular acidosis, which progressed to renal insufficiency, were evident. Due to a poor prognosis and perceived poor quality of life, the dog was humanely euthanased. Postmortem examination and histopathology revealed tubulointerstitial nephropathy. In conjunction with clinical uveitis, this presentation reflects similarities with the human oculorenal syndrome, here referred to as canine oculorenal syndrome suspected secondary to chronic zonisamide administration.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".