Desilylation‐Promoted Phosphine Catalysis: Intramolecular Annulation/Nucleophilic Addition Sequence of Trimethylsilylethynyl Benzoxazinanones with <i>N</i>‐Tosyl Imines
Bibliographic record
Abstract
Abstract Under phosphine catalysis facilitated through desilylation, intramolecular annulation/nucleophilic addition of trimethylsilylethynyl benzoxazinanones with electron‐deficient imines or alkenes was achieved to afford a series of indole derivatives in moderate to high yields. The trimethylsilylethynyl benzoxazinanones without electron‐withdrawing group on the alkyne moiety functioned as phosphine acceptors. Notably, the distinctive desilylation activation played a key role in catalytic process. Particularly, those indole derivatives could be readily transformed into various biologically significant γ‐carboline compounds. The use of chiral phosphine achieved asymmetric reaction, leading to a 95% ee of product.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.007 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".