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Record W4388364359 · doi:10.1016/j.ibneur.2023.08.260

DELAYED INTRASPINAL DELIVERY OF MRNAS ENCODING A COMBINATION OF CYTOKINES AND GDNF PROMOTES MORPHOLOGICAL AND FUNCTIONAL RECOVERY FOLLOWING SPINAL CORD INJURY

2023· article· en· W4388364359 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueIBRO Neuroscience Reports · 2023
Typearticle
Languageen
FieldMedicine
TopicSpine and Intervertebral Disc Pathology
Canadian institutionsAcuitas Therapeutics (Canada)
Fundersnot available
KeywordsGlial cell line-derived neurotrophic factorSpinal cord injurySpinal cordNeuroscienceMedicineCell biologyBiologyNeurotrophic factorsInternal medicineReceptor

Abstract

fetched live from OpenAlex

Spinal cord injury results in irreversible tissue damage followed by limited recovery of function. Our earlier study has shown that a cocktail with recombinant human (h) interleukin-10 (hIL-10), interleukin-6 (hIL-6), macrophage inflammatory protein 1-alpha (hMIP-1-alpha) and glial cell line-derived neurotrophic factor (hGDNF) loaded via osmotic pump is able to induce neuroprotection and functional recovery following spinal cord contusion injury (at the level of thoracic 10 vertebra) in a rat model.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.888
Threshold uncertainty score0.384

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.049
GPT teacher head0.321
Teacher spread0.272 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it