UNDERSTANDING THE ROLE OF SYNGAP1 IN GABAERGIC CIRCUIT DEVELOPMENT AND FUNCTION
Bibliographic record
Abstract
Haploinsufficiency of Syngap1 gene encoding the Synaptic Ras- GTPase Activating protein is associated with intellectual disability, autism spectrum disorder and epilepsy. Syngap1 is a negative regulator of Ras and of AMPA receptor trafficking to the postsynaptic membrane, thereby regulating the process of synaptic plasticity and neuronal homeostasis. Loss of Syngap1 leads to alterations in synaptic plasticity, behavioral abnormalities and cognitive deficits in mouse models. In particular, several studies have shown that Syngap1 regulates the time course of the maturation of dendritic spines and glutamatergic synapses in excitatory neurons; In contrast, the role of Syngap1 in inhibitory, GABAergic neurons is relatively uncharted.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".