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Pharmacology of nicotine addiction

2004· book-chapter· en· W4388367595 on OpenAlexaboutno aff
Jack E. Henningfield, Neal L. Benowitz

Bibliographic record

Venuenot available
Typebook-chapter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicNicotinic Acetylcholine Receptors Study
Canadian institutionsnot available
Fundersnot available
KeywordsNicotineAddictionSubstance dependenceNicotine dependencePsychiatryMedicinePsychoactive substanceDrugPharmacology

Abstract

fetched live from OpenAlex

Abstract Since the 1980s, it has become recognized by clinicians, researchers, and public health experts that tobacco products are among the most addictive and deadly of all dependence producing substances (Royal College of Physicians 2000; WHO 2001). Nicotine meets all of the standard criteria for a dependence-producing drug and all types of tobacco products are capable of delivering dependence-producing levels of nicotine (US DHHS 1988; Royal Society of Canada 1989; Royal College of Physicians 2000). These conclusions are consistent with the neuropharmacology of nicotine (Henningfield et al. 1996), with clinical studies of nicotine dependence and withdrawal (e.g. Hughes et al. 1990; Henningfield et al. 1995a), and with the epidemiology of tobacco use and dependence (Giovino et al. 1995). In fact, if evaluated against the criteria used to determine the level of psychoactive scheduling set by the U.S. Controlled Substance Act or the World Health Organization’s Convention on Psychotropic Substances (described by McClain and Sapienza 1989; Vocci 1989), nicotine could be appropriately categorized as a controlled substance (Food and Drug Administration 1995, 1996).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.387
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.257
Teacher spread0.248 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7
Published2004
Admission routes1
Has abstractyes

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