OC 58.5 Cooperation between Platelet β1 and β3 Integrins in the Arrest of Bleeding Under Inflammatory Conditions in Mice
Bibliographic record
Abstract
ceramides 18:1/16:0 and 18:1/18:0, which are positively correlated with platelet hyperresponsiveness to multiple agonists and heightened thrombus formation in aged mice.Employing Mfsd2b-siRNA, we reveal that MkPs contribute to reduced expression of cellular senescence markers γ-H2A.X (telomere shortening) and p53 (cell cycle arrest), and caspase-3 (apoptosis), and increased expression of Sirt1, which is known to delay cellular senescence and rejuvenate aged cells.Conclusion(s): Our studies demonstrated that aging affects Mfsd2b expression in specific MkP subpopulations that regulate circulating S1P and ceramides.These findings indicate that modulation of sphingolipids and ceramides by deletion of Mfsd2b strongly regulates aging-related platelet hyperreactivity and thrombus formation, which suggests that targeting Mfsd2b in specific MkP subpopulations could contribute to important clues to future personalized medicine for the prevention of thrombotic disorders in aging.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".