Bibliographic record
Abstract
Diabetes causes a decrease in cavernosal nitric oxide (NO) bioavailability that is associated with a diminished erectile response.The purpose of this study was to determine whether adenoviral-mediated overexpression of endothelial nitric oxide synthase (ENOS) could restore NO production and erectile function.Three groups of animals were utilized: 1) age matched control rats, 2) streptozotocin (STZ)-induced diabetic rats (65 mg/kg ip) transfected with AdCMV˚gal, and 3) STZ-rats with AdCMVeNOS.One day after transfection, these study animals underwent cavernosal nerve stimulation (CNS) to assess erectile function.eNOS and nNOS protein levels (Western blot), NOS activity (L-arginine to L-citrulline conversion), cGMP and nitrate + nitrite levels (ELISA) were assessed in cavernosal tissue from all three groups of animals.Diabetic animals had significant decreases in cavernosal nNOS, NOS activity, cGMP and nitrate + nitrite levels.One day after administration of AdCMVeNOS, eNOS protein, NOS activity, cGMP and nitrate + nitrite levels in the corpora cavernosa were significantly increased (P<0.05) to levels similar to control animals.STZ-rats had a significantly decreased erectile function as determined by CNS when compared to control rats.The increase in cavernosal pressure in response to CNS was enhanced in STZrats transfected with eNOS that was similar to control rats.Enhanced expression of eNOS employing an adenoviral vector restored erectile function in the diabetic rat.These data suggest that gene-transfer of eNOS may constitute a new therapeutic intervention for the treatment of diabetic ED.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".