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Efficacy and safety of ligelizumab in adults and adolescents with chronic spontaneous urticaria: results of two phase 3 randomised controlled trials
Marcus Maurer, Luís Felipe Ensina, Ana M. Giménez‐Arnau, Gordon Sussman, Michihiro Hide, Sarbjit S. Saini, Clive Grattan, Daria Fomina, Dimitrios Rigopoulos, F. Bérard, Giorgio Walter Canonica, Heike Röckmann, Carla Irani, Jacek C. Szepietowski, Jeffrey Leflein, Jonathan A. Bernstein, Jonny Peter, Kanokvalai Kulthanan, Kiran Godse, Ledit Ardusso, Olga Ukhanova, Petra Staubach, Rodney Sinclair, S. Gogate, Simon Francis Thomsen, Tonny Tanus, Young‐Min Ye, Alis Burciu, Avantika Barve, Darshna Modi, Emil Scosyrev, Eva Hua, Kerstin Letzelter, Vineeth Varanasi, Manmath Patekar, Thomas Severin, Agondi Rosana, A. Ahmed, Almerigogna Fabio, Alonso Miguel Angel Tejedor, Ammoury Alfred, Anne Goh Eng Kim, A Robert, Ardusso Ledit, Arenberger Petr, AS Nandini, Asefi Mohammad, A.C Aditya Natalia, Badhwar Anil, Baldrich Esther Serra, Bangert Christine, Barbaud Annick, Bata-Csorgo Zsuzsanna, Bauer Andrea, Berard Frederic, Bergler-Czop Beata, Berman Gary D, Bernstein Jonathan, Bharija Subhash Chandra, Bhat Ramesh M, Boccon-Gibod Isabelle, Botev Ivan, Brockow Knut, B. Philipp, Busse Paula, Campos Regis, Carmen Julia Maria Del, Carpio Jaime Del, C Mamatha, Yoon‐Seok Chang, Cheema Amarjit, Chen Yi Hsing, Yuko Chinuki, Cho Soyun, Choi Jeong-Hee, Chu Chia-Yu, Confino Ronit, Corren Jonathan, Criado Roberta, Cruz Claudia De La, Cypcar David M, Daftary Pramila, Danilycheva Inna, Dawes Kenneth, De Vera Michelle Joy, Deangelo James, Del Giacco Stefano, Diana Deleanu, D. Martínez-St John, D. Richard, Denguezli Mohamed, Dickel Heinrich, Doanh Le Huu, Dogan Sinan, Doutre Marie Sylvie, Dupond Anne Sophie, Edin Anton, Edward Kent, Ekanayake-Bohling Swarna, Daniel Elbirt, Elkayam David, E Anne, Shaunagh Emanuel, Emeliyanov Alexander, Engin Burhan, Ensina Luis Felipe, Ercoreca Ignacio Antepara, Ergun Safiye, Estebaranz Jose Luis Lopez, Fassakhov Rustem, Fomina Daria, Ford Linda, Francomano Mariangela, Funkhouser Todd, Gagnon Remi, Galimberti Ricardo, G Alberto, Galvao Clovis, Gattolin Gabriel, Ghislain Pierre-Dominique, Gimenez Arnau Ana Maria, Ginchansky Elliot, Giordano-Labadie Francoise, Givirovsky Stanislav, Godse Kiran, Gogate Shaila, Goldsobel Alan, Gomez Francisca, Gomez Rene Maximiliano, Gonzalez Erika, Gonzalez Paula Ribo, Gospodinov Dimitar, Grattan Clive, Grosber Martine, G. William Gary, Guimera Martin-Neda Francisco Jose Gomez, Gyulai Rolland, Hadvabova Svetlana, Hadzavdic Suzana Ljubojevic, Hamam Hadi, Hasicova Daniela, Koremasa Hayama, Pravin Hissaria, Hjerppe Anna, Hlinka Ivan, Horrillo Moises Labrador, Hsu Connie, Huang Yu-Huei, Hussain Iftikhar, Atsuyuki Igarashi, IMKO-WALCZUK Beata, Inaloz Huseyin Serhat, Intravaia Rossella, Jain Neal, Jain Sanjeev, Thilo Jakob, Javier Ruth Cerino, João Lourenço Francisco António, Jozefowicz Luiza Marek, Chang‐Gyu Jung, Kaatz Martin, Kacar Nida, Kanarek Henry, Karlova Iva, Kastanayan Alexander, Kazandjieva Jana, K. -J. Johannes, Neena Khanna, Heejoo Kim, Kim Nancy, Kim Sang-Ha, Tae-Bum Kim, Kingo Kulli, Kleinheinz Andreas, Komova Janka, Evangelia Kompoti, Kozub Peter, Krasowska Dorota, Krecisz Beata, Kreft Burkhard, Kubota Satsuki, Kudo Hitoshi, K. Teja, Kulthanan Kanokvalai, Kume Akihiro, Kupczyk Maciej, Lain Edward, Lanier Bobby, Hilde Lapeere, Lasanta Griselle Ortiz, Lazareva Svetlana, Lazzeri Laura, Ledford Dennis, Donghun Lee, L Franklin Jeffrey, Leitz Nicolas, L Mathis Nancy, Lima Hermenio, Lippert Undine, Lipson Brian, L. G. De Paula, Gabriel Magariños, M.V.S. Satyaprakash, M. S. Michail, M. d l S. C. Alejandro, Manjra Ahmed Manjra, Manning Michael, Manrique Maria, Marcipar Adriana, Marini Mariano, Monte Marco Del, M. M. Jorge, Tomoko Matsuda, Matz Jonathan, McFalda Wendy, Mclaughlin Anne, Medina Iris, M Dutt, Meller Stephan, MELTZER Steven, Meshkova Raisa, Mihalache Dorin, Miquel Francisco Javier, M. Mokni, Jessica E. Molhoek, Montano Efrain, Mueller Sabine, Munoz Javier Pedraz, Nagakura Toshikazu, Narbutt Joanna, N Figueras, Nebrida-Idea Ma. Lourdes M, N. Hoffmann Johannes, Ninet Violeta Zaragoza, Noguchi Hiromitsu, Nomura Yuko Chinuki, Roman Nowicki, Tokuya Omi, Onder Robert, Orojan Ivan, Ortiz de Frutos Francisco Javier, P K Kim, Parisi Claudio, Park Chun Wook, Park Young Min, Parra Viviana, Passeron Thierry, Pasteur Justine, Patil Shivakumar, Patrascu Vergil, Pauser Sylvia, Pelc Anna Wojas, Peter J. Grant, Pfuetzner Wolfgang, Pimpinelli Nicola, Pinter Andreas, Pizarro Cristian, Pizinger Karel, Plutinska Jarmila, Popov Todor, Popova Veronika, Puga Marta Ferrer, Pulido Lara Ferrandiz, Purcaru Anca, Raap Ulrike, Rajchel Anna, Ramey John, Ramiscal Ma Deanna Santos, Ramon German Dario, Rehman Syed, Reich Adam, Norbert Reider, Ress Krista, Rigopoulos Dimitrios, Rivas Enrique, Rockmann Heike, Roquet-Gravy Pierre-Paul, Rottem Menachem, Rowell Vermen Verallo, Rueff Franziska, Ruiz Juan Alberto Ruano, Russo Juan, S. Ronald, Saini Sarbjit, Salazar Maria, Salvador Juan Francisco Silvestre, Sanchez Jorge, Florica Şandru, S. Mark, Schaekel Knut, Sibylle Schliemann, Rik Schrijvers, Schwarz Beate, Schwinn Andreas, Sekhsaria Sudhir, Nilgün Şentürk, Seo Seong Jun, Serna Mercedes Rodriguez, Serpa Faradiba, Shapero Paul A, Shinkawa Eriko, Simon Jan‐Christoph, Sinclair Rodney, Singer Ralfi, Shah Franky D, Sitz Karl, Smialowski Adam, Smith Andrew, Soerensen Morten, Wiebke Sondermann, Song Haejun, S Mikhalik Dmitrii, Soong Weily, Soteres Daniel, Staevska-Kotasheva Maria, Staubach-Renz Petra, Subash Nisha Su Yien, Sussman Gordon, Svensson Ake Svensson, Syrigou Ekaterini, Andrea Szegedi, Szepietowski Jacek, Shunsuke Takahagi, Tal Yuval, Talreja Neetu, Tan Ricardo, Tang Jyh Jong, Tanus Tonny, Tarpay Martha, Tee Shang Ian, Teller Craig, Tetart Florence, Thanh Aurelie Du, Thevarajah Suganthi, Thomsen Simon Francis, Thornblade Carl, Tolcachier Alberto, Tolentino Celeste, Tsianakas Athanasios, Tsingov Ilia, Ukhanova Olga, Ulrich Jens, Meltem Uslu, Valenzuela Fernando, Valle Solange, van Doorn Martijn, Vankova Jirina, Vartak Suneel, Vidouria Christine, V. J. Sebastian, Volcheck Gerald, Wagner Nicola, Walecka-Herniczek Irena, Wattanakrai Penpun, Wedi Bettina, W J Lamberts Steven, Wessagowit Vesarat, Windom Hugh, Akiko Yagami, Yamamoto Aisaku, Yasumoto Shinichiro, Min Ye, Yepez Jose Cevallos, Youn Sang Woong, Hana Zelenková, Ziganshin Oleg, Zook Matthew
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
Bibliographic record
VenueThe Lancet · 2023
Typearticle
Languageen
FieldMedicine
TopicUrticaria and Related Conditions
Canadian institutionsUniversity of Toronto
FundersCharles Sturt UniversityNovartis Animal Health
KeywordsMedicinePhase (matter)PediatricsInternal medicinePhysical therapy
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.021
Threshold uncertainty score0.237
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.020
GPT teacher head0.307
Teacher spread0.287 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itQuick stats
Citations64
Published2023
Admission routes1
Has abstractno