Nickel-Catalyzed sp3 C–H Activation
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract Base metal catalyzed C–H activation represents a highly atom economic method to access functionalized molecules. This Account will focus on Ni-catalyzed C–H activation of sp3-hybridized carbon atoms with a particular focus on mechanism, recent applications, challenges, and outlook in this area. This Account will primarily focus on recent mechanistic work from 2017–2023.1 Base Metal C–H Activation 2 Nickel-Catalyzed sp3 C–H activation 3 Differences between Ni and Pd 4 Mechanistic Considerations 5 Elementary Steps 6 Directed sp3 C–H Activation 7 Choice of Directing Group 8 Primary C–H Activation 9 Secondary C–H Activation 10 Tertiary C–H Activation 11 Conclusion and Outlook
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.008 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it