Effects of Eccentric and Concentric Cycling Exercise Regimens on Hypoxia‐Mediated Mitochondrial Bioenergetics of Platelets in Sedentary Males
Bibliographic record
Abstract
Rehabilitation Science, Medical College, Chang Gung University, Taoyuan City, Taiwan Physical exercise influences platelet function according to responses dependent on the type and intensity of exercise. Mitochondrial bioenergetics is a critical role in the platelets function. The purpose of this study was to investigate the effects of eccentric (ECE) and concentric (CCE) cycling exercise regimens on mitochondrial oxidative phosphorylation of platelets during hypoxic stress. Twenty‐two healthy sedentary men were randomized to either ECE (n=11) or CCE (n=11) group. These subjects progressively performed ECE or CCE at 45% to 70% VO 2max on a bicycle ergometer for 40 min/day, 5 days/week for 6 weeks. Mitochondrial oxidative phosphorylation were measured by a high resolution respirometer (Oxygraph‐2k) at rest and after hypoxia exercise test (HE, 100W under 12% O 2 for 40 min). The result demonstrated that both ECE and CCE regimens increased complex I‐linked O 2 consumption rate (OCR), complex‐II linked OCR, fatty acid oxidation (FAO)‐linked OCR and GpDH‐linked OCR. Besides, ECE significantly diminished the suppressions of complex II‐ and GpDH‐linked respirations during HE. Hence, either ECE or CCE effectively enhances efficacy of mitochondrial oxidative phosphorylation in platelets. Moreover, ECE has more superior to alleviate the extent of mitochondrial dysfunction evoked by hypoxia stress.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".