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Skin Preparations from Catfish (Arius bilineatus, Val.) Contain a Lipid Which Inhibits Cancer Cell Survival <i>In Vitro</i>

2016· article· en· W4389026819 on OpenAlexaff
Jassim M. Al‐Hassan, Mohammad Afzal, Bincy Paul, Sosamma Oommen, Yuan Fang Liu, C.R. Pace-Asciak

Bibliographic record

VenueThe FASEB Journal · 2016
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicBee Products Chemical Analysis
Canadian institutionsSickKids FoundationHospital for Sick ChildrenUniversity of Toronto
FundersKuwait Foundation for the Advancement of Sciences
KeywordsCatfishIn vitroK562 cellsIC50ChemistryChromatographyBiologyBiochemistry

Abstract

fetched live from OpenAlex

The Catfish (Arius bilineatus, Val.) secretes a gelatinous substance composed of biochemically active lipids and proteins from its skin upon stress or injury. Preparations from the skin have previously been shown to affect blood clotting, accelerates healing of non‐healing diabetic foot ulcers and relief from neuropathic pain in man 1 . Chromatographic separation of the crude lipid preparation on silica gel column gave a fraction eluted with chloroform that apoptosed human cancer cell lines (K562 and DU‐145) in vitro , observed IC50 was between 5 – 10 ug/0.1ml/1e4 cells. Identification of the active substance(s) is currently under way. Support or Funding Information (Supported by a grant from Kuwait Foundation for the Advancement of Science No. KFAS 201320701A‐D, and Kuwait University Research Grant No. SL03/14).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.014
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.217
Teacher spread0.202 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2016
Admission routes1
Has abstractyes

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