Evidence that Epithelial Tight Junctions are Altered during <i>Edwardsiella</i> Infections
Bibliographic record
Abstract
Bacteria from the Edwardsiella genus can kill entire fish farms within days. These infections cause an array of phenotypic alterations to fish including petechial hemorrhage in the fins and skin, rectal hernia, abscesses deep within fish musculature and most strikingly, holes within (or the liquefaction of) the fish themselves. Intercellular junctions are crucial for maintaining tissue integrity, but are also common targets of bacterial pathogens. Because Edwardsiella causes alterations to various epithelia during their infectious processes, we hypothesized that tight junctions (TJs) might be targeted by these microbes. To test this hypothesis, we localized the claudin‐3 transmembrane tight junction protein in Caco‐2 cells during Edwardsiella infections and found that it was extensively re‐arranged. This work provides the first evidence of junctional alteration during Edwardsiella infections, and suggests a possible molecular modification that could lead to the observed phenotypes in diseased fish. Support or Funding Information Funded by NSERC Discovery Grant
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.002 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".