Perinatal Resveratrol Supplementation to Spontaneously Hypertensive Rat Dams Mitigates the Development of Hypertension in Adult Offspring
Bibliographic record
Abstract
Background The spontaneously hypertensive rat (SHR) is a model of essential hypertension in which high blood pressure (BP) develops after 7 wks of age. Altered vascular resistance profiles and renal hemodynamics are evident by 3 wks of age, implicating these early functional changes as a cause, rather than a consequence, of hypertension in this model. As such, the developmental period before weaning may constitute a critical time for therapeutic intervention. Objective This study was undertaken to determine whether perinatal maternal resveratrol (Resv)—a phytoalexin known to confer cardiovascular protection—could prevent the development of hypertension and improve vascular function in adult SHR offspring. Methods SHR dams were fed either a control or a Resv‐supplemented diet (4g/kg diet) from gestational day 0.5 until postnatal day 21. Indwelling catheters were used to assess BP and vascular function in vivo; wire myography was used to assess vascular reactivity ex vivo . Results Perinatal Resv supplementation in dams had no effect on fetal body weights, albeit continued maternal treatment postnatally resulted in growth restriction in offspring by PD21; growth restriction was no longer evident after 5 wk of age. Maternal perinatal Resv supplementation prevented the onset of hypertension in adult offspring (−18mHg, P=0.007), and L‐NAME treatment normalized these BP differences, suggesting improved NO bioavailability underlies the BP reductions in the SHR+Resv group. In vivo and ex vivo, vascular responses to methylcholine were not different between treatment groups, but prior treatment with L‐NAME attenuated the vasodilation in SHR, but not SHR+Resv adult offspring, suggesting a shift towards NO‐independent vascular control mechanisms in the treated group. Finally, bioconversion of the inactive precursor bET‐1 to active ET‐1 in isolated mesenteric arteries was reduced in SHR+Resv offspring (−28%; P<0.05), and this difference could be normalized by L‐NAME treatment. Conclusion Perinatal Resv mitigated the development of hypertension and causes persistent alterations in vascular responsiveness in SHRs. Support or Funding Information This work is funded by grants from the Canadian Institutes of Health Research and the Women and Children's Health Research Institute through the generous contributions of the Stollery Children's Hospital Foundation and the Royal Alexandra Hospital Foundation. AC was supported by fellowships from the National Health and Medical Research Council of Australia, Alberta Innovates ‐ Health Solutions, and the Heart and Stroke Foundation of Canada; SD is a Canada Research Chair in Maternal and Perinatal Cardiovascular Health.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".