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Record W4389071214 · doi:10.36692/v15n3-33r

THE INTERACTION BETWEEN ADVANCED TECHNOLOGIES AND THE BIOMEDICAL IN THE TREATMENT OF GENETIC DISEASES: A BIBLIOGRAPHIC REVIEW

2023· review· en· W4389071214 on OpenAlex
Rafaele Fernanda Oliveira Caes, Ana Beatriz Silva Nunes, Franciele Nazário Brigido, Tayná Humeniuk Azevedo, Gabriel Vitor da Silva Pinto, Lucas Trevizani Rasmussen, Luciano Lobo Gatti, Douglas Fernandes da Silva

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueRevista CPAQV - Centro de Pesquisas Avançadas em Qualidade de Vida · 2023
Typereview
Languageen
FieldMedicine
TopicBiotechnology and Related Fields
Canadian institutionsAdidas (Canada)
Fundersnot available
KeywordsBiomedicineContext (archaeology)Genome editingCRISPRBiomedical technologyPersonalized medicinePrecision medicineEmerging technologiesEngineering ethicsMedicineBiotechnologyData scienceBioinformaticsComputer scienceBiologyEngineeringGeneticsGenePathologyArtificial intelligence

Abstract

fetched live from OpenAlex

Genetic manipulation is a promising approach to treating diseases caused by genetic defects. Gene therapy has experienced notable advances, allowing the replacement or manipulation of dysfunctional genes; Genome editing techniques such as CRISPR-Cas9 and CRISPR-Cas12a have been developed and represent long-lasting approaches to treating genetic diseases. The role of the biomedical scientist, with his interdisciplinary training in molecular biology and genetics, is essential in this context. The advancement of molecular and biotechnology technologies promotes new perspectives in the diagnosis, treatment, and prevention of diseases, revolutionizing medicine and improving the health of the population. OBJECTIVE: This study aims to list new genetic technologies in the context of disease treatment, with the aim of supplying pertinent data for future research in genetic manipulation. Additionally, we look to highlight the role of biomedicine in the current technological and scientific panorama. METHODOLOGY: Literary bibliographic surveys selected through specific platforms were used to analyze article data, using specific criteria; In the end, 9 articles were selected. CONCLUSIONS: The researched literature showed that technological innovations in gene therapy present revolutionary perspectives for medicine, by offering promising treatment possibilities for diseases of genetic and bought origin. In this context, biomedical scientists play a significant role, conducting research, implementing therapies, and providing guidance, with the aim of ensuring the safety and effectiveness of these therapeutic approaches.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity
Consensus categoriesResearch integrity
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.964
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0010.005
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.360
Teacher spread0.328 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it