Nivolumab-Induced Limbic Encephalitis Associated with Glutamic Acid Decarboxylase 65 Antibodies (P8-1.003)
Bibliographic record
Abstract
Immune checkpoint inhibitor (ICI) therapies have improved the overall survival rates of patients with various advanced malignancies. ICIs target and block immune inhibitory receptors, including programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) and programmed cell death ligand 1 (PD-L1) expressed by both tumoral cells and healthy tissues. Systemic and neurological immune-related adverse events (irAEs) are well-known side effects of ICI. We report a case of autoimmune limbic encephalitis secondary to the intracellular antigen Glutamic Acid Decarboxylase (GAD) 65 in the context of nivolumab therapy for stage IV melanoma in a 40-year-old female. Treatment included high doses of intravenous methylprednisolone, five sessions of plasma exchange and cyclophosphamide without any improvement.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".