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Record W4389375913 · doi:10.1177/19427786231215673

CRISPR futures: Rethinking the politics of genome editing

2023· article· en· W4389375913 on OpenAlexaboutno aff
Amedeo Policante, Erica Borg

Bibliographic record

VenueHuman Geography · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCRISPR and Genetic Engineering
Canadian institutionsnot available
FundersFundação para a Ciência e a Tecnologia
KeywordsCommercializationPoliticsIndigenousPolitical scienceEconomic growthBiologyEconomicsEcologyLaw

Abstract

fetched live from OpenAlex

New genome editing techniques such as CRISPR-Cas9 aspire to automate and standardize laboratory practices of genetic engineering at the molecular scale. They have been promoted as a ‘revolutionary’ means of production, which will revitalize industry, transform agribusiness and adapt it to changing climatic conditions. To realize this vision, a fundamental regulatory shift is now being enacted by multiple national governments around the world from Argentina to Canada, Brazil, Australia, South Africa, the United States, the United Kingdom, Japan, China and the European Union. As corporate science is directly in the service of private entities guided by a strict market rationality, while public research is increasingly pushed to prioritize immediate ‘industrial applications’ and the achievement of measurable ‘socio-economic impact’, genomic interventions are mostly geared towards expanding , accelerating and securing the accumulation of capital on a global scale. Structural market demands are embodied in gene-edited bodies produced for commercialization. While the emerging international regulatory regime for gene-edited organisms has been largely shaped by discussions focused on technical questions of health and safety, this tendency indicates the necessity of a wider democratic debate that would include the socio-economic, ethical and ecological concerns recently stressed by indigenous and peasant movements around the world. How will these new GM bodies transform the way people live and work in agricultural lands, industrial facilities, barnyards and slaughterhouses, in biotech labs and medical clinics? How will they affect lived ecologies? What types of multi-species worlds are being constructed through bioengineering practices, by whom and according to what political visions?

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.027
metaresearch head score (Gemma)0.023
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesScience and technology studies
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.994
Threshold uncertainty score0.140

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0270.023
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0060.044
Scholarly communication0.0130.018
Open science0.0020.007
Research integrity0.0090.016
Insufficient payload (model declined to judge)0.0080.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.291
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations6
Published2023
Admission routes1
Has abstractyes

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