Pro-inflammatory cytokines levels in tears and dry eye disease in Parkinson’s disease
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Background: Neuroinflammation is an essential event in Parkinson’s disease (PD). Identifying affordable and less invasive biomarkers to make an early diagnosis and monitor therapeutic strategies should be a priority among researchers. The study’s objective was to measure tear levels of cytokines in subjects with PD and their association with motor features and the presence of dry eye symptoms. Methods: A total of 16 subjects with PD and 16 age- and sex-matched controls were included. Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), Hoehn and Yahr (HY) stage scale, Montreal Cognitive Assessment (MoCA), tear break-up time (TBUT), blink rate (BR), Dry Eye Questionnaire 5 (DEQ-5) were examined, and pro-inflammatory cytokines [interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12p70 and tumor necrosis factor-alpha (TNF-α)] were quantified in tears using the BD Cytometric Bead Array Human Inflammatory Cytokine Kit. Results: Higher tear TNF-α were quantified in PD compared to controls (2.94±3.95 vs. 0.33±0.49 pg/mL, P=0.008). According to DEQ-5, 50.0% (n=8) of PD subjects and 12.5% (n=2) controls had dry eye disease (DED). No differences were found in cytokines concentrations between PD patients with DED compared to those without DED. IL-8 was associated with the HY stage, TBUT, DEQ-5, and a better MoCA score. A higher BR correlated moderately with a lower HY stage (r=−0.645, P=0.007), and DED patients have lower BR in PD (12.14±2.54 vs. 9.0±2.06 blinks/minute, P=0.031). Conclusions: PD patients have higher levels of TNF-α in tears than age- and sex-matched HC. IL-8 in tears may be both involved in the severity of the disease and in the development of DED in PD. In addition, our findings suggest that as HY stage increases, indicating a more advanced stage, BR decreases, indicating greater motor impairment. Conversely, the presence of DED is associated with higher levels of bradykinesia in PD patients, suggesting a potential relationship between DED and motor impairment severity.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it