Cortical Excitability After Mild Traumatic Brain Injury in Children (P3.288)
Bibliographic record
Abstract
Objective: To determine if cortical excitability is different in pediatric mTBI one month after injury, and if this is related to symptom persistence. Background: Mild traumatic brain injury (mTBI) is common, and children are at an increased risk for persistent symptoms. The reasons for this are unclear. Cortical inhibition may be altered following adult mTBI. We hypothesized that cortical excitability may be different following pediatric mild TBI, and may differ in children who remain symptomatic. Methods: A cross-sectional controlled cohort study was performed. Children (aged 8-18 years) with mTBI were recruited as part of the PlayGame Trial (www.playgametrial.ca). Participants were grouped into those returning to pre-injury symptom scores (asymptomatic) and those with persistent symptoms (symptomatic) at one month using the post-concussion symptom inventory. Healthy controls had no history of brain injury. Single and paired-pulse TMS protocols were performed. The primary outcome measure was cortical silent period (cSP). Secondary outcomes included stimulus-response curves (SRC), intracortical facilitation (ICF), and short and long interval intracortical inhibition (SICI/LICI). Results: Twenty-five symptomatic, 23 asymptomatic, and 25 controls were studied. Groups were similar in age (control median [range]: 14.49 [8.4-18.8], asymptomatic: 14.76 [9.3-17.9], and symptomatic: 15.34 [8.3-17.0] years), sex, and time post-injury (symptomatic: 40 [32-54], asymptomatic 40.5 [28-57] days). cSP was similar across groups (mean [95[percnt] confidence interval]): 114.58 [95.53 - 133.63] in controls, 115.89 [97.78 - 134] in asymptomatic, and 104.15 [86.34 - 121.96] in symptomatic children, (F (2, 70) = 0.53, p = 0.591). No differences in SRC, SICI, LICI, or ICF were observed across groups. Procedures were well tolerated with no adverse events. Conclusions: TMS is well tolerated by children following mTBI. Unlike similar studies in adult mTBI, children with mTBI did not show altered cortical excitability at one month post-injury.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".