Copper‐Catalyzed α‐Arylation of Sulfoxonium Ylides Using Hypervalent Iodine Compounds
Why this work is in the frame
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Bibliographic record
Abstract
Abstract A Cu(I)‐catalyzed synthesis of α‐arylated sulfoxonium ylides has been achieved from mesitylene‐derived diaryliodonium salts and α‐carbonyl sulfoxonium ylides. The reaction is believed to proceed via an electrophilic Cu(III)‐aryl intermediate that can be trapped upon nucleophilic attack of the sulfoxonium ylide precursor. The reaction was tolerant to both α‐keto and α‐ester‐derived sulfoxonium ylides, to drug‐derived ylide motifs and to electronically‐diverse arenes, and enabled the direct synthesis of 32 α‐aryl‐sulfoxonium ylides in 42–85% yield.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it