Bibliographic record
Abstract
PTB Reports,2023,9,1,20-22.DOI:10.5530/PTB.2023.9.3Published:November 2023Type:Drug ReviewAuthors:Juman Alsaab Author(s) affiliations:Juman Alsaab, Pharm D,Ministry of Health, Riyadh, SAUDI ARABIA. Abstract:Registrations: Tirzepatide has been registered in the following countries United States of America (USA), United Kingdom (U.K.), Canada, Saudi Arabia (S.A.). Trade name (USA): MOUNJARO Registration number (S.A.); Not Available. Insurance Drug Formulary (S.A.); Not covered (28.1.2023). General Information: Registered Company: Lilly USA. Regulatory Status: R.X. Mechanism of Action: Tirzepatide is a Glucose-dependent Insulinotropic Polypeptide (GIP) receptor and Glucagon-Like Peptide-1 (GLP-1) receptor agonist. It is a 39-amino acid-modified peptide containing a C20 fatty diacid component that facilitates albumin binding and increases the halflife. Tirzepatide preferentially binds to and activates GIP and GLP- 1 receptors, hence targeting endogenous GIP and GLP. Tirzepatide increases the first and second phases of insulin secretion and decreases glucagon levels in a glucose-dependent manner. Tirzepatide reduces fasting and postprandial glucose levels, food consumption, and body weight in people with type 2 diabetes. Indication: Type 2 diabetes mellitus. View:PDF (230.22 KB) PDF PDF Images Drug Review: Tirzepatide
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".