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Record W4389624765 · doi:10.5530/ptb.2023.9.8

Drug Review: Eflapegrastim

2023· article· en· W4389624765 on OpenAlexaboutno aff
Juman Alsaab

Bibliographic record

VenuePharmacology Toxicology and Biomedical Reports · 2023
Typearticle
Languageen
FieldMedicine
TopicCytokine Signaling Pathways and Interactions
Canadian institutionsnot available
Fundersnot available
KeywordsChristian ministryFormularyDrugPharmacologyMedicinePolitical science

Abstract

fetched live from OpenAlex

A recombinant human granulocyte growth factor activates signaling pathways that affect cell differentiation, proliferation, migration, and survival by binding to G-CSF receptors on myeloid progenitor cells and neutrophils. IndicationIn patients with non-myeloid malignancies taking myelosuppressive anti-cancer medications, a clinically significant incidence of febrile neutropenia is associated with myelosuppressive anti-cancer drugs; Prophylaxis. Route of Administration: Sub-Q.Dosage Forms: Subcutaneous Solution: 13.2 MG/0.6 ML.Dosing/Administration: 13.2 mg sub Q administered once per chemotherapy cycle as a single injection approximately 24 hr after cytotoxic chemotherapy.Do not administer within the period from 14 days before to 24 hr after administration of cytotoxic.Chemotherapy; do not administer within the period from 14 days before to 24 hr after administration of cytotoxic chemotherapy.Dose: Dose in Renal/Hepatic failure: No dosage adjustment is needed. Geriatric Dose: No dosage adjustment is needed.Adjustment required in Specific population: No dosage adjustment is needed.Indicated for pediatrics: Safety and effectiveness not established in pediatric patients.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.074
Threshold uncertainty score0.248

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0020.001
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0740.049

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.366
Teacher spread0.341 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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