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Record W4389829793 · doi:10.1111/nan.12947

<i>LMNB1</i> ‐duplication mediated nuclear architecture alteration and demyelination of cerebral white matter in a patient with ADLD

2023· article· en· W4389829793 on OpenAlexaff
Vincent Roy, Isabella Bienjonetti, Alyssa Brodeur, Laurence Dion‐Albert, Lydia Touzel‐Deschênes, Peter V. Gould, Stéphan Saïkali, Robert Laforce, François Gros‐Louis

Bibliographic record

VenueNeuropathology and Applied Neurobiology · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAmino Acid Enzymes and Metabolism
Canadian institutionsCentre hospitalier universitaire de QuébecUniversité Laval
Fundersnot available
KeywordsWhite matterCerebellumImmunohistochemistryAutopsyPathologyAnatomyMedicineBiologyNeuroscienceMagnetic resonance imagingRadiology

Abstract

fetched live from OpenAlex

FIGURE S1: Macroscopic examination of the posterior brain. FIGURE S2: Specific histochemical and immunohistochemical stainings performed on mid-sagittal sections from the patient's cerebellum at the level of the middle cerebellar peduncle. FIGURE S3: White matter vacuolar changes. FIGURE S4: Representative immunohistochemical staining of post-mortem white matter of the parietal lobe. FIGURE S5: Additional examination of nuclei in post-mortem CNS tissues from the ADLD patient. Table S1: Clinical information from autopsy cases Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.930
Threshold uncertainty score0.459

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.003
GPT teacher head0.184
Teacher spread0.180 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2023
Admission routes1
Has abstractyes

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