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Record W4389858821 · doi:10.21203/rs.3.rs-3676579/v1

Unagi: Deep Generative Model for Deciphering Cellular Dynamics and In-Silico Drug Discovery in Complex Diseases

2023· preprint· en· W4389858821 on OpenAlexafffund
Yumin Zheng, Jonas C. Schupp, Taylor Adams, Gérémy Clair, A. Justet, Farida Ahangari, Xiting Yan, Paul Hansen, Marianne Carlon, Emanuela Elsa Cortesi, Marie Vermant, Robin Vos, Laurens De Sadeleer, Iván O. Rosas, Ricardo Pineda, John Sembrat, Mélanie Königshoff, John E. McDonough, Bart Vanaudenaerde, Wim Wuyts, Naftali Kaminski, Jun Ding

Bibliographic record

VenueResearch Square · 2023
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCell Image Analysis Techniques
Canadian institutionsMcGill University
FundersFonds de Recherche du Québec - SantéCanadian Institutes of Health ResearchElse Kröner-Fresenius-StiftungU.S. Department of DefenseMedizinischen Hochschule HannoverDeutsche ForschungsgemeinschaftNiedersächsisches Ministerium für Wissenschaft und Kultur
KeywordsIn silicoDrug discoveryGenerative grammarComputational biologyDrugComputer scienceDynamics (music)Drug repositioningArtificial intelligenceBiologyBioinformaticsPharmacologyPsychologyGenetics

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.639
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.002
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.052
GPT teacher head0.381
Teacher spread0.330 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2023
Admission routes2
Has abstractno

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