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Record W4389882562 · doi:10.32920/24625167.v1

Investigating a Fractional Derivative Approach to Tumour Growth and Irradiation Modelling

2023· preprint· en· W4389882562 on OpenAlexaff
Nicole Wilson

Bibliographic record

Venuenot available
Typepreprint
Languageen
FieldMathematics
TopicMathematical Biology Tumor Growth
Canadian institutionsToronto Metropolitan UniversityUniversity of Waterloo
Fundersnot available
KeywordsRadiation therapyCancerFractional calculusDerivative (finance)MedicineComputer scienceMathematicsApplied mathematicsInternal medicineEconomics

Abstract

fetched live from OpenAlex

<p>Cancer is one of the foremost causes of death worldwide. Although significant strides forward are continually being made, researchers often revisit foundational questions as newer and better technol- ogy is developed. One fundamental question that piques the interest of clinicians and researchers, alike, is the optimization of cancer- and patient-speci▯c treatment schedules. Mathematical on- cology, while still in its infancy, uses mathematics, modelling, and simulation to study cancer and thus improve our understanding of the disease and its treatments. This thesis focuses on comparing ordinary and fractional di▯erential equation models of tumor growth and radiation. Patient data from the Mo▯tt Cancer Centre is used to ▯t our six candidate models. These results are analyzed to assess the usefulness of the fractional derivative for our particular application and to compare our approach to existing industry standards. Collectively, our analysis shows that mathematical modelling is an invaluable tool to the future of oncology research. iii</p>

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.322
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.167
GPT teacher head0.326
Teacher spread0.160 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designTheoretical or conceptual
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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