Effect of Vitamin D Supplementation on Regulatory T Cells of Systemic LupusErythematosus: A Systematic Review
Bibliographic record
Abstract
Background. Systemic lupus erythematosus (SLE) is associated with aglobal reduction in regulatory T cells (Tregs). Vitamin D supplementationthat is efficacious, safe, and reasonably priced has the potential to reducemorbidity in SLE. This study was aimed to systematically assess the efficacyof vitamin D supplementation in enhancing Tregs concentration or Tregsrelated marker. Methods. A systematic review of the literature for clinicalstudies was performed on Pubmed, Proquest, and Google Scholar. Studieswere assessed for risk of bias using Newcastle Ottawa Scale. All clinicalstudies that investigated the effects of vitamin D supplementation on Tregsin SLE patients were included. Key evidence was analyzed and qualitativelysynthesized. Results. Three relevant studies were included. All studies wereof high-quality. Vitamin D supplementation consistently increased Tregsconcentration across all included studies. Conclusion. The current studysupports the evidence that vitamin D supplementation enhanced Tregsconcentration in SLE patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.015 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.007 | 0.006 |
| Bibliometrics | 0.007 | 0.006 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".