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Record W4389956306 · doi:10.36838/v5i6.8

The Molecular Basis of Cystic Fibrosis

2023· article· en· W4389956306 on OpenAlexaff
Lydia Zheng

Bibliographic record

VenueInternational journal of high school research · 2023
Typearticle
Languageen
FieldMedicine
TopicCystic Fibrosis Research Advances
Canadian institutionsBayer (Canada)
Fundersnot available
KeywordsCystic fibrosisMedicineComputational biologyInternal medicineBiology

Abstract

fetched live from OpenAlex

Cystic Fibrosis is the most common autosomal recessive disorder that affects Caucasians.It is caused by a mutation of the expression of the CF transmembrane conductance regulator (CFTR) gene, which has over 2,500 noted variants, spawning irregular chloride channels in mucus and sweat-producing cells.The disease causes damage to the respiratory system and GI tract until the organs fail to function by causing thick mucus to build up in the lungs and pancreas.As the chronic disease currently has no cure, people with this condition can generally live normal lives, as many tools and techniques can be used to manage this complex condition.However, this does not mean that patients live perfectly healthy lives, as they still experience symptoms such as shortness of breath and coughing.This review article summarises the pathology and pathomechanism of the disease, what it is on a genetic expression level, and emerging therapies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.015
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.430
Threshold uncertainty score0.993

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.015
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.035
GPT teacher head0.420
Teacher spread0.384 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2023
Admission routes1
Has abstractyes

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