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Fear and pain slow the brain

2023· article· en· W4389959500 on OpenAlexaffabout
Ali Mazaheri, Andrew J. Furman

Bibliographic record

VenuePain · 2023
Typearticle
Languageen
FieldMedicine
TopicIntensive Care Unit Cognitive Disorders
Canadian institutionsWestern University
FundersNational Institute of Neurological Disorders and Stroke
KeywordsMedicinePsychologyNeurosciencePhysical medicine and rehabilitation

Abstract

fetched live from OpenAlex

Neurophysiological signals detected non-invasively at the scalp using techniques such as EEG/MEG contain rhythms (oscillatory activity) occurring at distinct frequency bands.The predominant rhythm in healthy humans occurs between the bandwidth of 8-14 Hz, and is commonly referred to as the alpha rhythm.The frequency within the alpha band where power is maximal is called the peak alpha frequency (PAF) or individual alpha frequency.PAF varies considerably between individuals [10; 15] and this variability is believed to play a role in the individual differences in perceptual ability and temporal binding of sensory information [1; 9; 21; 23].The relationship of PAF to both acute and chronic pain is an exciting area currently under investigation by multiple laboratories.Patients with chronic pain often exhibit changes in alpha rhythms, particularly slower PAF, when compared to control subjects [26], and the degree of PAF slowing has been found to correlate with chronic pain duration [4].One interpretation of this PAF slowing is that it reflects brain processes that actively maintain chronic pain, such as excess "inhibition or disfacilitation" brought about by ongoing pain [16].An alternative interpretation is that slower PAF reflects processes related to higher pain sensitivity and an increased disposition to develop chronic pain that predate disease onset.This latter interpretation is supported by a series of studies of acute pain in heathy subjects, which found that an individual's PAF recorded during a pain-free rest period was negatively correlated with the intensity of a future pain event [6][7][8].This work has undergone initial clinical validation: in a cohort of patients undergoing thoracotomy, PAF collected prior to surgery was able to predict the severity of post-surgery pain [20].Thus, PAF has been suggested as a biomarker of pain sensitivity which has been hypothesized to be a key factor in the transition from acute to chronic pain [11].Precisely how PAF fits into the myriad of biological, social, and psychological factors involved in the transition from acute to chronic pain has remained unexplored.One of these

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.023
Threshold uncertainty score0.076

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0020.001
Open science0.0000.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0230.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.268
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2023
Admission routes2
Has abstractyes

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