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Beyond smallpox: The emergence of monkeypox as a threat to human health - symptoms and treatment

2023· article· en· W4390007004 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueTheoretical and Natural Science · 2023
Typearticle
Languageen
FieldImmunology and Microbiology
TopicPoxvirus research and outbreaks
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsMonkeypoxSmallpoxVirologyOrthopoxvirusPoxviridaeMedicineVacciniaVaccinationBiology

Abstract

fetched live from OpenAlex

A double-stranded DNA pox virus known as monkeypox is a member of the Poxviridae family, which is divided into the West African and Congo Basin clades. Spreading originally from countries in Africa. Monkeypox has since spread to numerous other countries and was proclaimed a worldwide health emergency. There are no current treatments designed for monkeypox, therefore it is important to discuss the therapeutic options and prevention methods. For the symptomatic management of monkeypox, antiviral medications are utilized. Numerous studies conducted in animal models proved the safety and efficiency of antiviral drugs designed for monkeypox, despite the risk factors. The monkeypox virus can also be prevented by using previous smallpox vaccines. Here, we focus on the epidemiology, the transmission and the pathology of monkeypox. Further, we review the current therapies and vaccines for monkeypox to help to limit the spread and influence of monkeypox, and further, to bring insight in further studies involving antiviral drugs and vaccines to treat monkeypox.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesScience and technology studies
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.401
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.004
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.317
Teacher spread0.304 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it