The Utility of Allopregnanolone as an Objective Screening Tool for Postpartum Depression: A Systematic Review
Bibliographic record
Abstract
PPD is defined as a major depressive episode that coincides with peripartum onset, meaning symptom occurrence during pregnancy or within four weeks of delivery. METHODSSearch strategy A systematic literature review was done using PubMed and EBSCO.EBSCO services were used to search MEDLINE, Academic Search Premier, CINAHL Ultimate, and Cochrane Central Register of Controlled Trials.Grey literature was also searched using Medrxiv and Google Scholar.The following boolean/phrase search strategy was used with the following terms, ( " p o s t p a r t u m d e p r e s s i o n " o r " p o s t n a t a l depression" or "ppd" or "pnd" or "post-partum depression" or "post-natal depression") AND ("allopregnanolone" OR "allo").Databases were searched from inception through September 6th, 2023.This search strategy was developed with the assistance of the Sacred Heart University Health Sciences Librarian on August 31, 2023. Participant or populationPersons over the age of 18 who are pregnant or within one year of pregnancyPregnant persons. Intervention Measurement of ALLO serum levels during pregnancy.Comparator N/A. Study designs to be included All study designs measuring serum ALLO in currently pregnant or postpartum patients.Eligibility criteria Participants over the age of 18 who are pregnant or within one year of pregnancy, studies available in the English language, studies measuring serum ALLO in currently pregnant or postpartum patients, mood disorder outcomes measured with validated depression and anxiety inventory scales.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.009 | 0.036 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.009 | 0.008 |
| Bibliometrics | 0.011 | 0.010 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".