MCPIP1 Controls the Effects of Myeloid Cells on Skin Carcinogenesis and Hair Growth
Bibliographic record
Abstract
Monocyte chemotactic protein-induced protein-1 (MCPIP1), or Regnase-1, is an RNase with anti-inflammatory properties (Matsushita et al. 2009). Expression of MCPIP1, encoded by the gene ZC3H12A, is impaired in several types of cancer (Miekus et al. 2019). As the immune system is a key element in the etiology of cancers, we hypothesized that MCPIP1 of myeloid cells is important in the crosstalk between the immune system and cells of developing tumors. To test this hypothesis, we used mice lacking Mcpip1 in cells of myeloid origin (Mcpip1MKO), including macrophages and granulocytes, in a chemical carcinogenesis model of epithelial skin cancer.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".