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Record W4390394118 · doi:10.5858/arpa.2023-0446-le

In Support of Magnani and Taylor

2023· article· en· W4390394118 on OpenAlexaff
David J. Dabbs, Luis Chiriboga, Bharat Jasani, Mary Kinloch, Keith D. Miller, Søren Nielsen, Matthias Szabolcs, Emina Torlakovic, Steve Bogen, Suzanne Parry, Nils A. ‘t Hart

Bibliographic record

VenueArchives of Pathology & Laboratory Medicine · 2023
Typearticle
Languageen
FieldMedicine
TopicClinical Laboratory Practices and Quality Control
Canadian institutionsUniversity of SaskatchewanRoyal University HospitalSaskatchewan Health Authority
FundersIrving Medical Center, Columbia UniversityNational Cancer InstituteMedical Center, University of PittsburghAalborg UniversitetshospitalUniversity of PittsburghAalborg UniversitetCardiff UniversityTufts Medical Center
KeywordsChecklistQuality assuranceAccreditationStatement (logic)MedicinePathologyPsychologyMedical educationLawPolitical scienceExternal quality assessment

Abstract

fetched live from OpenAlex

We, the undersigned, endorse the proposal published by Barbarajean Magnani, MD, PhD, and Clive Taylor, MD, Dphil,1 in their recent Archives of Pathology & Laboratory Medicine editorial. The time has come to acknowledge that immunohistochemistry is used as an assay, not only a stain, and merits the higher level of quality assurance associated with immunoassays.2 Although the editorial does not prescribe specific new regulations, we share the view expressed in the Magnani-Taylor editorial that existing quality assurance requirements for immunoassays—learned after decades of experience—are a reasonable starting point. This statement is intended to raise awareness, stimulate discussion, and express support for much-needed improvements to clinical immunohistochemistry laboratory practice to enhance patient care. The planning of the 2026 immunohistochemistry accreditation checklist should begin now.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.724
Threshold uncertainty score0.439

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.038
GPT teacher head0.372
Teacher spread0.335 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2023
Admission routes1
Has abstractyes

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