Record W4390545560 · doi:10.1038/s41467-023-44090-5

Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

2024· article· en· W4390545560 on OpenAlexaff

Al Ozonoff, Naresh Doni Jayavelu, Shanshan Liu, Esther Melamed, Carly E. Milliren, Jingjing Qi, Linda N. Geng, Grace A. McComsey, Charles B. Cairns, Lindsey R. Baden, Joanna Schaenman, Albert C. Shaw, Hady Samaha, Vicki Seyfert‐Margolis, Florian Krammer, Lindsey B. Rosen, Hanno Steen, Caitlin Syphurs, Ravi Dandekar, Casey P. Shannon, Rafick‐Pierre Sékaly, Lauren I. R. Ehrlich, David B. Corry, Farrah Kheradmand, Mark A. Atkinson, Scott C. Brakenridge, Nelson Iván Agudelo Higuita, Jordan P. Metcalf, Catherine L. Hough, William B. Messer, Bali Pulendran, Kari C. Nadeau, Mark M. Davis, Ana Fernández-Sesma, Viviana Simon, Harm van Bakel, Seunghee Kim‐Schulze, David A. Hafler, Ofer Levy, Monica Kraft, Chris Bime, Elias K. Haddad, Carolyn S. Calfee, David J. Erle, Charles Langelier, Walter L. Eckalbar, Steven E. Bosinger, Kerry McEnaney, Brenda Barton, Claudia Lentucci, Mehmet Saluvan, Ana C. Chang, Annmarie Hoch, Albert Marisa, Tanzia Shaheen, Alvin T. Kho, Sanya Thomas, Jing Chen, Maimouna D. Murphy, Mitchell Cooney, Arash Nemati Hayati, Robert W. Bryant, James Abraham, Scott Presnell, Tomasz Jancsyk, Cole Maguire, Brian Lee, Slim Fourati, Denise Esserman, Leying Guan, Jeremy P. Gygi, Shrikant Pawar, Anderson F. Brito, Gabriela K. Fragiadakis, Ravi K. Patel, Scott J. Tebbutt, James A. Overton, Randi Vita, Kerstin Westendorf, Rama Thyagarajan, Justin F. Rousseau, Dennis Wylie, Todd Triplett, Erna Milunka Kojic, R. Sharon Chinthrajah, Neera Ahuja, Angela J. Rogers, Maja Artandi, George A. Yendewa, Debra Powell, James N. Kim, Brent Simmons, I. Michael Goonewardene, Cecilia M. Smith, Mark G. Martens, Amy C Sherman, Stephen R. Walsh, Nicolas C. Issa, Ramin Salehi‐Rad, Charles S. Dela Cruz, Shelli Farhadian, Akiko Iwasaki, Albert I. Ko, Evan J. Anderson, Aneesh K. Mehta, Jonathan Sevransky, Aleksandra Leligdowicz, Michael A. Matthay, Jonathan P. Singer, Kirsten N. Kangelaris, Carolyn M. Hendrickson, Matthew F. Krummel, Prescott G. Woodruff, Matthew Lee Anderson, Faheem W. Guirgis, Douglas A. Drevets, Brent R. Brown, Sarah Siegel, Zhengchun Lu, Jarrod Mosier, Hiroki Kimura, Bernard Khor, Adeeb Rahman, Daniel Stadlbauer, Jayeeta Dutta, Ana S. Gonzalez‐Reiche, Adriana van de Guchte, Juan Manuel Carreño, Gagandeep Singh, Ariel Raskin, Johnstone Tcheou, Dominika Bielak, Hisaaki Kawabata, Hui Xie, Geoffrey Kelly, Manishkumar Patel, Kai Nie, Temima Yellin, M. Fried, Leeba Sullivan, Sara Morris, Scott F. Sieg, Patrick van Zalm, Benoit Fatou, Kevin Mendez, Jessica Lasky‐Su, Scott R. Hutton, Gregory A. Michelotti, Kari E. Wong, Meenakshi Jha, Arthur Viodé, Naama Kanarek, Boryana Petrova, Yujiao Zhao, Arun K. Boddapati, Greg K. Tharp, Kathryn L. Pellegrini, Elizabeth Beagle, David Cowan, Sydney Hamilton, Susan Pereira Ribeiro, Thomas Hodder, Serena Lee, Michael R. Wilson, Bonny D. Alvarenga, Jayant V. Rajan, Andrew Schroeder, Alexandra Tsitsiklis, Eran Mick, Yanedth Sanchez Guerrero, Christina Love, Lenka Maliskova, Michael Adkisson, Nadia Siles, Janelle N. Geltman, Kerin Hurley, Miti Saksena, Deena R. Altman, Komal Srivastava, Lily Eaker, Maria C. Bermúdez‐González, Katherine F. Beach, Levy A. Sominsky, Arman R. Azad, Lubbertus C. F. Mulder, Giulio Kleiner, Alexandra S. Lee, Evan Do, Andrea Fernandes, Monali Manohar, Thomas Hagan, Catherine A. Blish, Hena Din, Jonasel Roque, Samuel Yang, Natalia Sigal, Iris Chang, Heather Tribout, Paul Harris, Mary Consolo, Jennifer Connors, Mariana Bernui, Michele A. Kutzler, Carolyn Pope Edwards, Edward Lee, Edward Lin, Brett Croen, Nicholas C. Semenza, Brandon Rogowski, Nataliya Melnyk, Kyra Woloszczuk, Gina Cusimano, Matthew R. Bell, Sara Furukawa, Renee McLin, Pamela Schearer, Julie Sheidy, George P. Tegos, Crystal Nagle, Kinga K. Smolen, Michaël Desjardins, Simon van Haren, Xhoi Mitre, Jessica Cauley, Xiaofang Li, Alexandra Tong, Bethany Evans, Christina Montesano, Jose Humberto Licona, Jonathan Krauß, Jun Bai Park Chang, Natalie Izaguirre, Rebecca Rooks, David Elashoff, Jenny Brook, Estefania Ramires‐Sanchez, Megan Llamas, Adreanne Rivera, Claudia Perdomo, Dawn C. Ward, Clara E. Magyar, Jennifer A. Fulcher, Harry Pickering, Subha Sen, Omkar Chaudhary, Andreas Coppi, John Fournier, Subhasis Mohanty, M. Catherine Muenker, Allison Nelson, Khadir Raddassi, Michael Rainone, William Ruff, Syim Salahuddin, Wade L. Schulz, Pavithra Vijayakumar, Hao‐Wei Wang, Elsio A. Wunder, H. P. Young, Jessica E. Rothman, Anna Konstorum, Ernie Chen, Chris Cotsapas, Nathan D. Grubaugh, Xiaomei Wang, Leqi Xu, Hiromitsu Asashima, Laurel Bristow, Laila Hussaini, Kieffer Hellmeister, S. Wimalasena, Andrew Cheng, Christine Spainhour, Erin M. Scherer, Brandi Johnson, Amer Bechnak, Caroline Ciric, Lauren T. Hewitt, Erin Carter, Nina McNair, Bernadine Panganiban, Christopher Huerta, Jacob Usher, Tatyana Vaysman, Steven M. Holland, Yumiko Abe‐Jones, Saurabh Asthana, Alexander J. Beagle, Sharvari Bhide, Sidney Carrillo, Suzanna Chak, Rajani Ghale, Ana Gonzalez, Alejandra Jáuregui, Norman L. Jones, Tasha Lea, Deanna Lee, Raphael Lota, Jeff Milush, Viet Nguyen, Logan Pierce, Priya A. Prasad, Arjun A. Rao, Bushra Samad, Cole Shaw, Austin Sigman, Pratik Sinha, Alyssa Ward, Andrew Willmore, Jenny Zhan, Sadeed Rashid, Nicklaus Rodriguez, Kevin Tang, Luz Torres Altamirano, Legna Betancourt, Cindy Curiel, Nicole Sutter, Maria Tercero Paz, Gayelan Tietje-Ulrich, Carolyn Leroux, Neeta Thakur, Joshua Vasquez, Lekshmi Santhosh, Li-Zhen Song, Ebony Nelson, Lyle L. Moldawer, Brittany Borresen, Brittney Roth-Manning, Ricardo Ungaro, Jordan Oberhaus, J. Leland Booth, Lauren A. Sinko, Amanda E. Brunton, Peter E. Sullivan, Matthew Strnad, Zoë L. Lyski, Felicity J. Coulter, Courtney Micheleti, Michelle Conway, David Francisco, Allyson Molzahn, Heidi L. Erickson, Connie Cathleen Wilson, Ron Schunk, Bianca Sierra, Trina Hughes, Bjoern Peters, Steven H. Kleinstein, Elaine F. Reed, Alison D. Augustine, Joann Diray‐Arce, Holden T. Maecker, Matthew C. Altman, Ruth R. Montgomery, Patrice M. Becker, Nadine Rouphael

Bibliographic record

VenueNature Communications · 2024

Typearticle

Languageen

FieldMedicine

TopicLong-Term Effects of COVID-19

Canadian institutionsPrevention of Organ FailureSt. Paul's Hospital

FundersNational Institute of Allergy and Infectious DiseasesNational Heart, Lung, and Blood InstituteNational Institutes of HealthNational Center for Advancing Translational SciencesU.S. Department of Health and Human Services

KeywordsMedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)PhenotypeCluster (spacecraft)AntibodyReceptorImmunologyDiseaseInternal medicineBiologyInfectious disease (medical specialty)Gene

DOI10.1038/s41467-023-44090-5

Abstract

fetched live from OpenAlex

Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001

metaresearch head score (Gemma)0.005

Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated

Candidate categoriesnone

Consensus categoriesnone

DomainCandidate signal: none · Consensus signal: none

Study designCandidate signal: Observational · Consensus signal: none

GenreCandidate signal: Empirical · Consensus signal: Empirical

Teacher disagreement score0.827

Threshold uncertainty score0.808

Codex and Gemma teacher scores by category

Category	Codex	Gemma
Metaresearch	0.001	0.005
Meta-epidemiology (narrow)	0.000	0.000
Meta-epidemiology (broad)	0.001	0.000
Bibliometrics	0.000	0.001
Science and technology studies	0.000	0.000
Scholarly communication	0.000	0.000
Open science	0.002	0.000
Research integrity	0.000	0.002
Insufficient payload (model declined to judge)	0.000	0.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034

GPT teacher head0.386

Teacher spread0.352 · how far apart the two teachers sit on this one work

Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.

Study designObservational

Domainnot available

GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations57

Published2024

Admission routes1

Has abstractyes

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