O0053 NORMAL GLOMERULAR FILTRATION RATE (GFR) IN LONG‐TERM FOLLOW‐UP OF CHILDREN AFTER ORTHOTOPIC LIVER TRANSPLANTATION (OLT)
Bibliographic record
Abstract
Introduction:Cyclosporine A(CyA) and tacrolimus(Tacro) are the principal immunosuppressive agents used for OLT in children.Progress ive deterioration of renal function from calcinerin inhibi tor (CNI) toxicity after OLT has been reported.Aim: To assess long-term renal function in children after OLT. Methods:We reviewed all OLT patients surviving >1 year at Saint-Justine Hospital from 1987 to 2003.The GFR was measured yearly by the Tc-99mDTPA single injection technique.Results: 101 OLT patients were included: tyrosinemia (Tyr) (27), biliary atresia (33), fulminant hepatic failure (5), and miscellaneous (36).Post-operative renal insufficiency required ATG in 5, and was associated with ganciclovir in 15 and amphotericin B in 9. Tyr patients were analysed separately from the rest (Others).Median age at OLT was 35 mo.(range 6-178) in Tyr group and 58 mo.(range 1-226) in the Others (p=ns).PELD score was 3 (range-9-21) and 15 (-9-50),p=0.001,mean follow-up 8.9(CI95% 7.6-10.1)and 6.7(CI95% 5.9-7.6)years, respectively.At 1 year post-OLT, 65/101 (64%) (9/18 Tyr) were on antihypertensive (a-h)therapy and at 5 years, 22/73 (30%) (9/17 Tyr).Mean duration of a-h therapy in Tyr group was 4.7(CI95% 3.4-6.1)vs. 2.5(CI 95% 1.9-3.1)years in the Others.Outcome: GFR remained stable in both groups in follow-up of up to 12 years (Tab 1).No differences in GFR occurred between groups by gender, CNI levels or per kg dose.CyA was switched to Tacro in 54 patients (53.5%), at a median of 5.5 years (range 1-13) after OLT.GFR did not differ on CyA vs Tacro; 86.9± 6.4, vs. 88.2±5.3(p=0.7) in Tyr group and 94.5 ±3.06 vs. 101.1±4.49(p=0.084) in Others group.In 6 patients, followed for 6-10 years, the GFR gradually decrea sed from 101-120 to 44-80.All 6 received CyA in 3 daily doses.Diltiazem was given in 3/6 patients; 2/6 received calcium antagonists.CyA was switched to Tacro in years 7 and 8 post-OLT in 3/6.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".