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Record W4390579943 · doi:10.1016/j.stemcr.2023.12.001

Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies

2024· article· en· W4390579943 on OpenAlexfundno aff
Yasuaki Iwama, Hiroko Nomaru, Tomohiro Masuda, Yōko Kawamura, Michiru Matsumura, Yuri Murata, Kazuki Teranishi, Kohji Nishida, Sadao Ota, Michiko Mandai, Masayo Takahashi

Bibliographic record

VenueStem Cell Reports · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicRetinal Development and Disorders
Canadian institutionsnot available
FundersCanadian Internet Registration AuthorityJapan Agency for Medical Research and Development
KeywordsBiologyRetinalInduced pluripotent stem cellRetinitis pigmentosaCell sortingTransplantationRetinal degenerationCell therapyProgenitor cellStem cellRegenerative medicineCell biologyCellEmbryonic stem cellBiochemistryMedicineSurgery

Abstract

fetched live from OpenAlex

The Eating Attitude Test-26 (EAT-26) is a widely used screening tool to measure symptoms and behaviors related to eating disorders (EDs). Previous studies in various countries have empirically assessed the original factor structure of EAT-26 based on their respective sample data. Their sample data did not support the original factor structure of EAT-26. Sociocultural factors may cause ED behaviors to differ among diverse sociocultural groups. However, assessing the EAT-26 factor structure using confirmatory factor analysis (CFA) has not been done in Thailand. Thus, this cross-sectional study aimed to examine the factor structure of EAT-26 among 210 young adults in Northeast Thailand using both exploratory factor analysis (EFA) and CFA. The results of our study revealed similar findings to those of previous studies. The first finding indicated that the factor structure of the EAT-26 was inconsistent with the sample data obtained using EFA. Similarly, the second CFA finding indicated that the (EAT-26) model did not fit the sample data. However, the sample data from those previous studies and our sample data differed from those included in the original EAT-26 study. In other words, the sample data come from those participants who did not share the same sociocultural backgrounds different than those included in the original EAT-26 study. It can be concluded that sociocultural factors appear to play a crucial role in the ED screening stage. Therefore, adapting the ED screening tools to suit groups with different sociocultural backgrounds (e.g., young Thai adults) may be essential. Finally, future research should focus on developing an ED scale bank that accommodates the growing screening tools sensitive to sociocultural factors.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.237
Teacher spread0.225 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations18
Published2024
Admission routes1
Has abstractyes

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