Primary Hyperparathyroidism in Biopsy-Defined Adult Celiac Disease
Bibliographic record
Abstract
Osteoporosis and secondary hyperparathyroidism commonly occur in celiac disease thought to be mainly due to impaired intestinal calcium and vitamin absorption.A 41-yr-old female diagnosed with celiac disease and osteoporosis in 1979 was on a life-long gluten-free diet.In 1997, she developed abdominal pain.Blood and abdominal imaging studies (ultrasound, CT and barium studies) were normal, except for a slightly elevated serum calcium level.Endoscopic studies showed rare gastric and duodenal bulbar erosions that responded initially to courses of ranitidine, and later, omeprazole.Serum gastrins were normal.Duodenal biopsies were normal with healed celiac disease.Later, serum calcium progressively increased with a rising parathyroid hormone (PTH) levels.Primary hyperparathyroidism was suspected and, in 2001, neck dissection showed a parathyroid gland adenoma that was resected.This completely resolved her prior persistent hypercalcemia and abdominal pain.Primary hyperparathyroidism due to a parathyroid adenoma is rare in celiac disease but may cause osteopenic bone disease, recurrent bouts of abdominal pain and mucosal erosions responsive to anti-secretory agents.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".