Pediatric pulmonary vascular disease associated with perinatal insults
Bibliographic record
Abstract
Pediatric pulmonary vascular disease such as pulmonary occlusive vasculopathy and pulmonary hypertension is associated with various perinatal insults, including fetal growth restriction and hypoxic-ischemic injury. However, the underlying mechanisms remain to be fully elucidated. In this symposium, I would like to introduce two studies related to the topic. One is a preclinical study demonstrating that perinatal hypoxia aggravates occlusive pulmonary vasculopathy in the offspring treated with hypoxia and SU5416 later in life. The global changes of DNA methylation in the smooth muscle cells caused by perinatal hypoxia may be associated with the phenotype. The other is a set of clinical studies showing that treatment of fetal growth restriction by sildenafil may increase the incidence of pulmonary hypertension in the newborn. Rebound vasoconstriction after cessation of sildenafil may be related to the pathophysiological mechanism. I would like to discuss how perinatal insults could affect pediatric pulmonary vasculature, considering the epigenetic change caused by hypoxia and the difference between PDE5 inhibitors.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".