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Record W4390694263 · doi:10.1038/s41586-023-06862-3

100 ancient genomes show repeated population turnovers in Neolithic Denmark

2024· article· en· W4390694263 on OpenAlexfundno aff
Morten E. Allentoft, Martin Sikora, Anders Fischer, Karl-Göran Sjögren, Andrés Ingason, Ruairidh Macleod, Anders Rosengren, Bettina Schulz Paulsson, Marie Louise Schjellerup Jørkov, Maria Novosolov, Jesper Stenderup, T. Douglas Price, Morten Fischer Mortensen, Anne Birgitte Nielsen, Mikkel Ulfeldt Hede, Lasse Sørensen, Poul Otto Nielsen, Peter Rasmussen, Theis Zetner Trolle Jensen, Alba Refoyo-Martínez, Evan K. Irving-Pease, William Barrie, Alice Pearson, Bárbara Sousa da Mota, Fabrice Demeter, Rasmus Amund Henriksen, Tharsika Vimala, Hugh McColl, Andrew H. Vaughn, Lasse Vinner, Gabriel Renaud, Aaron J. Stern, Niels Nørkjær Johannsen, Abigail Ramsøe, Andrew J. Schork, Anthony Ruter, Anne Birgitte Gotfredsen, Bjarne Henning Nielsen, Erik Brinch Petersen, Esben Kannegaard, Jesper Hansen, Kristoffer Buck Pedersen, Lisbeth Pedersen, Lutz Klassen, Morten Meldgaard, Morten Johansen, Otto Uldum, Per Lotz, Per Lysdahl, Pernille Bangsgaard, Peter Vang Petersen, Rikke Maring, Rune Iversen, Sidsel Wåhlin, Søren A. Sørensen, Søren H. Andersen, Thomas Martini Jørgensen, Niels Lynnerup, Daniel J. Lawson, Simon Rasmussen, Thorfinn Sand Korneliussen, Kurt H. Kjær, Richard Durbin, Rasmus Nielsen, Olivier Delaneau, Thomas Werge, Kristian Kristiansen, Eske Willerslev

Bibliographic record

VenueNature · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicForensic and Genetic Research
Canadian institutionsnot available
FundersH2020 Marie Skłodowska-Curie ActionsH. Lundbeck A/SNational Institute of General Medical SciencesNovo NordiskLundbeckfondenNational Institute on AgingAarhus Universitets ForskningsfondNational Institutes of HealthQueen's UniversitySchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungDeutsche ForschungsgemeinschaftSocial Sciences and Humanities Research Council of CanadaNational Research FoundationDanmarks GrundforskningsfondNovo Nordisk FondenQueen's University BelfastRiksbankens JubileumsfondAarhus UniversitetEuropean CommissionWellcome TrustVillum FondenNational Science Foundation
KeywordsGenomePopulationAncient DNABiologyGeographyEvolutionary biologyGeneticsDemographyGene

Abstract

fetched live from OpenAlex

Abstract Major migration events in Holocene Eurasia have been characterized genetically at broad regional scales 1–4 . However, insights into the population dynamics in the contact zones are hampered by a lack of ancient genomic data sampled at high spatiotemporal resolution 5–7 . Here, to address this, we analysed shotgun-sequenced genomes from 100 skeletons spanning 7,300 years of the Mesolithic period, Neolithic period and Early Bronze Age in Denmark and integrated these with proxies for diet ( 13 C and 15 N content), mobility ( 87 Sr/ 86 Sr ratio) and vegetation cover (pollen). We observe that Danish Mesolithic individuals of the Maglemose, Kongemose and Ertebølle cultures form a distinct genetic cluster related to other Western European hunter-gatherers. Despite shifts in material culture they displayed genetic homogeneity from around 10,500 to 5,900 calibrated years before present, when Neolithic farmers with Anatolian-derived ancestry arrived. Although the Neolithic transition was delayed by more than a millennium relative to Central Europe, it was very abrupt and resulted in a population turnover with limited genetic contribution from local hunter-gatherers. The succeeding Neolithic population, associated with the Funnel Beaker culture, persisted for only about 1,000 years before immigrants with eastern Steppe-derived ancestry arrived. This second and equally rapid population replacement gave rise to the Single Grave culture with an ancestry profile more similar to present-day Danes. In our multiproxy dataset, these major demographic events are manifested as parallel shifts in genotype, phenotype, diet and land use.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.002
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.291
Teacher spread0.283 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations114
Published2024
Admission routes1
Has abstractyes

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