Global Stability of a Delayed Model for the Interaction of SARS-CoV-2/ACE2 and Adaptive Immunity
Bibliographic record
Abstract
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the culprit behind the coronavirus disease 2019 (COVID-19), which has killed millions of people. SARS-CoV-2 binds its spike (S) protein to the angiotensin-converting enzyme 2 (ACE2) receptor to inter the epithelial cells in the respiratory tracts. ACE2 is a crucial mediator in the SARS-CoV-2 infection pathway. In this paper, we construct a mathematical model to describe the SARS-CoV-2/ACE2 interaction and the adaptive immunological response. The model predicts the effects of latently infected cells as well as immunological responses from cytotoxic T lymphocytes (CTLs) and antibodies. The model is incorporated with three distributed time delays: (i) delay in the formation of latently infected epithelial cells, (ii) delay in the activation of latently infected epithelial cells, (iii) delay in the maturation of new released SARS-CoV-2 virions. We show that the model is well-posed and it admits five equilibria. The stability and existence of the equilibria are precisely controlled by four threshold parameters Ri, i=0,1,2,3. By formulating suitable Lyapunov functions and applying LaSalle's invariance principle, we show the global asymptotic stability for all equilibria. To demonstrate the theoretical results, we conduct numerical simulations. We do sensitivity analysis and identify the most sensitive parameters. We look at how the latent phase, ACE2 receptors, antibody and CTL responses, time delays affect the dynamical behavior of SARS-CoV-2. Although the basic reproduction number R0 is unaffected by the parameters of antibody and CTL responses, it is shown that viral replication can be hampered by immunological activation of antibody and CTL responses. Further, our findings indicate that R0 is affected by the rates at which the ACE2 receptor grows and degrades. This could provide valuable guidance for the development of receptor-targeted vaccines and medications. Furthermore, it is shown that, increasing time delays can effectively decrease R0 and then inhibit the SARS-CoV-2 replication. Finally, we show that, excluding the latently infected cells in the model would result in an overestimation of R0.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".