MétaCan
Menu
Back to cohort
Record W4391036002 · doi:10.1016/j.it.2023.12.003

Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond

2024· article· en· W4391036002 on OpenAlexfundno aff
Mehul Sharma, Narissara Suratannon, Daniel Leung, Safa Barış, Ichiro Takeuchi, Simran Samra, Kumiko Yanagi, Jaime S. Rosa Duque, Mehdi Benamar, Kate L. Del Bel, Mana Momenilandi, Vivien Béziat, Jean‐Laurent Casanova, P. Martin van Hagen, Katsuhiro Arai, Ichiro Nomura, Tadashi Kaname, Pantipa Chatchatee, Hideaki Morita, Talal A. Chatila, YL Lau, Stuart E. Turvey

Bibliographic record

VenueTrends in Immunology · 2024
Typearticle
Languageen
FieldImmunology and Microbiology
TopicImmunodeficiency and Autoimmune Disorders
Canadian institutionsnot available
FundersCanadian Institutes of Health ResearchNational Institutes of HealthUniversité de ParisInstitut National Du CancerFondation Schlumberger pour l’Education et la RechercheThailand Science Research and InnovationMarmara ÜniversitesiInstitut des maladies génétiques ImagineUniversity of British ColumbiaChulalongkorn UniversityCroucher FoundationInstitut National de la Santé et de la Recherche MédicaleAgence Nationale de la RechercheJapan Agency for Medical Research and DevelopmentGenome British ColumbiaAgence Nationale de Recherches sur le Sida et les Hépatites ViralesBC Children's HospitalBC Children’s Hospital FoundationRockefeller UniversityLi Ka Shing FoundationSt. Giles FoundationGovernment of CanadaChildren's Hospital FoundationHoward Hughes Medical Institute
KeywordsSTAT6STAT proteinDiseaseImmunologyImmune systemPhenotypeGermlineMedicineGain of functionAllergyBiologyInterleukin 4GeneticsSTAT3Internal medicineGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.924
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.256
Teacher spread0.246 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations43
Published2024
Admission routes1
Has abstractno

Explore more

Same venueTrends in ImmunologySame topicImmunodeficiency and Autoimmune DisordersFrench-language works237,207