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Record W4391277257 · doi:10.54097/jhenwt17

Applications of CA125 in Ovarian Cancer

2023· article· en· W4391277257 on OpenAlexaff
Wanlin Wu

Bibliographic record

VenueHighlights in Science Engineering and Technology · 2023
Typearticle
Languageen
FieldImmunology and Microbiology
TopicImmunotherapy and Immune Responses
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsOvarian cancerMedicineOncologyComputer scienceCancerInternal medicine

Abstract

fetched live from OpenAlex

Ovarian cancer is currently the most fatal among gynecological malignancies with a low survival rate, especially in the case of type II tumors. Cancer antigen 125, the primary protein biomarker associated with ovarian cancer, has been researched for its involvement in the ovarian cancer pathogenesis and its potential applications in enhancing both accurate diagnostics and effective therapies. Research has investigated the connections between CA125 and several biological pathways, revealing their associations with cancer cell proliferation and migration. Further research aims to utilize CA125 for a more accurate diagnosis and potential treatments for ovarian cancer. Approaches have been established to address the low specificity of CA125 diagnostic tests, including altering the traditional CA125 value threshold used for ovarian cancer diagnosis and detecting CA125 alongside other antigens. CA125-specific cancer vaccines and immunotherapies are currently undergoing clinical trials and are being developed for future clinical use.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.002
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.239
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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