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Record W4391278552 · doi:10.1111/cea.14456

Plant‐produced Der p 2‐bearing bioparticles activate Th1/Treg‐related activation patterns in dendritic cells irrespective of the allergic background

2024· article· en· W4391278552 on OpenAlexaffabout
Stefanie Busold, Lorenz Aglas, Charlotte Menage, Réjean Desgagnés, Loı̈c Faye, Anne‐Catherine Fitchette, Esther C. de Jong, Caroline Martel, Maria Stigler, Virginie Stordeur, Guy Tropper, Lydia Auger, Bertrand Morel, Serge A. Versteeg, Louis‐P. Vézina, Véronique Gomord, Janice A. Layhadi, Mohamed H. Shamji, Teunis B. H. Geijtenbeek, Ronald van Ree

Bibliographic record

VenueClinical & Experimental Allergy · 2024
Typearticle
Languageen
FieldMedicine
TopicAllergic Rhinitis and Sensitization
Canadian institutionsInstitute of Infection and Immunity
FundersEuropean Academy of Allergy and Clinical ImmunologyImperial College LondonUniversität SalzburgAllergy TherapeuticsImmune Tolerance Network
KeywordsImmunologyTreg cellDendritic cellBiologyAllergyMedicineImmune systemT cellIL-2 receptor

Abstract

fetched live from OpenAlex

Plant-produced Der p 2-bearing bioparticles activate Th1/Tregrelated activation patterns in dendritic cells irrespective of the allergic backgroundTo the Editor, Allergen immunotherapy (AIT) is the only disease-modifying treatment for allergic diseases with proven sustained efficacy, but long treatment duration, chronic exposure to aluminium salts and allergic side-effects are major drawbacks.AIT aims to redirect the underlying T helper type 2 (Th2)-skewed immune response towards an allergen-

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0070.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.053
GPT teacher head0.346
Teacher spread0.293 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2024
Admission routes2
Has abstractyes

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