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Record W4391404075 · doi:10.1007/s11538-023-01244-2

Ranked Subtree Prune and Regraft

2024· article· en· W4391404075 on OpenAlexaff
Lena Collienne, Chris Whidden, Alex Gavryushkin

Bibliographic record

VenueBulletin of Mathematical Biology · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomics and Phylogenetic Studies
Canadian institutionsDalhousie University
FundersMinistry of Business, Innovation and EmploymentRoyal Society Te ApārangiMarsden FundUniversity of Canterbury
KeywordsPhylogenetic treeTree (set theory)AlgorithmComputer scienceRanking (information retrieval)Artificial intelligenceCombinatoricsMathematicsMachine learningBiologyGene

Abstract

fetched live from OpenAlex

Phylogenetic trees are a mathematical formalisation of evolutionary histories between organisms, species, genes, cancer cells, etc. For many applications, e.g. when analysing virus transmission trees or cancer evolution, (phylogenetic) time trees are of interest, where branch lengths represent times. Computational methods for reconstructing time trees from (typically molecular) sequence data, for example Bayesian phylogenetic inference using Markov Chain Monte Carlo (MCMC) methods, rely on algorithms that sample the treespace. They employ tree rearrangement operations such as [Formula: see text] (Subtree Prune and Regraft) and [Formula: see text] (Nearest Neighbour Interchange) or, in the case of time tree inference, versions of these that take times of internal nodes into account. While the classic [Formula: see text] tree rearrangement is well-studied, its variants for time trees are less understood, limiting comparative analysis for time tree methods. In this paper we consider a modification of the classical [Formula: see text] rearrangement on the space of ranked phylogenetic trees, which are trees equipped with a ranking of all internal nodes. This modification results in two novel treespaces, which we propose to study. We begin this study by discussing algorithmic properties of these treespaces, focusing on those relating to the complexity of computing distances under the ranked [Formula: see text] operations as well as similarities and differences to known tree rearrangement based treespaces. Surprisingly, we show the counterintuitive result that adding leaves to trees can actually decrease their ranked [Formula: see text] distance, which may have an impact on the results of time tree sampling algorithms given uncertain "rogue taxa".

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.007
Threshold uncertainty score0.025

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.009
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.002
Science and technology studies0.0010.002
Scholarly communication0.0020.004
Open science0.0020.002
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0070.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.243
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2024
Admission routes1
Has abstractyes

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