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Record W4391426559 · doi:10.1016/j.euo.2024.01.004

External Validation of a Digital Pathology-based Multimodal Artificial Intelligence Architecture in the NRG/RTOG 9902 Phase 3 Trial

2024· article· en· W4391426559 on OpenAlexaff
Ashley E. Ross, Jingbin Zhang, Huei–Chung Huang, Rikiya Yamashita, Jessica Keim‐Malpass, Jeffry Simko, Sandy DeVries, Todd M. Morgan, Luís Souhami, M.C. Dobelbower, L.S. McGinnis, Christopher U. Jones, Robert T. Dess, Kenneth L. Zeitzer, Kwang Nam Choi, Alan C. Hartford, Jeff M. Michalski, Adam Raben, Leonard G. Gomella, Oliver Sartor, Seth A. Rosenthal, Howard M. Sandler, Daniel E. Spratt, Stephanie L. Pugh, Osama Mohamad, Andre Esteva, Emmalyn Chen, Edward M. Schaeffer, Phuoc T. Tran, Felix Y. Feng

Bibliographic record

VenueEuropean Urology Oncology · 2024
Typearticle
Languageen
FieldComputer Science
TopicAI in cancer detection
Canadian institutionsMcGill University Health Centre
FundersNational Cancer InstituteFoundation MedicineUniversity of California, San FranciscoEMD SeronoAstellas PharmaEndocyteAdvanced Accelerator ApplicationsNRG OncologyVarian Medical SystemsSanofiInvitaeBristol-Myers SquibbAstraZenecaAmgenPfizer
KeywordsMedicineHazard ratioConfidence intervalOncologyInternal medicineRandomized controlled trialClinical trialProportional hazards modelHistopathologyPathology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.963
Threshold uncertainty score0.616

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.041
GPT teacher head0.332
Teacher spread0.291 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designOther design
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations26
Published2024
Admission routes1
Has abstractno

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