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Record W4391652645 · doi:10.1038/s41556-023-01343-1

Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal

2024· article· en· W4391652645 on OpenAlex
Laura Newman, Sammy Weiser Novak, Gladys R. Rojas, Nimesha Tadepalle, Cara R. Schiavon, Danielle A. Grotjahn, Christina G. Towers, Marie‐Ève Tremblay, Matthew P. Donnelly, Sagnika Ghosh, Michaela Medina, Sienna Rocha, Ricardo Rodriguez-Enriquez, Joshua A. Chevez, Ian Lemersal, Uri Manor, Gerald S. Shadel

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueNature Cell Biology · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMitochondrial Function and Pathology
Canadian institutionsUniversity of Victoria
FundersNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Neurological Disorders and StrokeNational Institute of General Medical SciencesNational Cancer InstituteWaitt FoundationUniversity of TorontoFondation pour la Recherche MédicaleGeorge E. Hewitt Foundation for Medical ResearchJohns Hopkins UniversityPioneer FundNational Institutes of HealthAmerican Heart AssociationNational Science FoundationYale UniversityNational Eye InstituteNational Institute on AgingGlenn Foundation for Medical Research
KeywordsCell biologyNucleoidEndosomeDNA replicationDNABiologyChemistryGeneticsGeneIntracellular

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.283
Threshold uncertainty score0.907

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.244
Teacher spread0.239 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it