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Record W4391749453 · doi:10.31482/mmsl.2024.003

MOLECULAR CHARACTERIZATION, CLINICAL MANAGEMENT AND DEVELOPMENT OF THE VACCINES AGAINST THE TARGETED VIRAL COMPONENTS OF COVID-19

2024· article· en· W4391749453 on OpenAlexaff
Taha Nazir, Marya Ahmed, Hameed A. Mirza, Nida Taha

Bibliographic record

VenueMilitary Medical Science Letters · 2024
Typearticle
Languageen
FieldMedicine
TopicSARS-CoV-2 and COVID-19 Research
Canadian institutionsYork UniversityUniversity of Prince Edward IslandAmgen (Canada)
Fundersnot available
KeywordsCoronavirus disease 2019 (COVID-19)VirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakCharacterization (materials science)Computational biologyMedicineBiologyNanotechnologyMaterials sciencePathologyInfectious disease (medical specialty)

Abstract

fetched live from OpenAlex

Spike proteins on the surface of human corona viruses is important to enhance it's competency to get transmit into other healthy population.Because of it's specific spike protein, the virus got its name corona in 1960s.Afterward, it was renamed as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) in 2002 and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in 2012.It was mortal for old population, new born babies and immune-compromised individuals, who didn't have sufficient immunity or defense system.On February 11, 2020, World Health Organization (WHO) gave the names of COVID-19 and SARS-CoV-2.A characteristic of nCoV-19, which is a cause of COVID-19, was identified as major cause of pneumonia.However, the healthcare professionals worked hard to to stop it's outbreak and transmission all over the world.But, there was no medicines that have been cleared by the FDA to treat COVID-19 successfully.So, the goal of this study is to look at the scientific data that is already available about clinical care and therapy of this disease.Some of the sources that were checked for this study were BioRxiv, medRxiv, Google Scholar, Embase, PsychINFO, WanFang Data, and PubMed.A lot of work went into finding out what medicines could be used to avoid and treat COVID-19 illnesses.Remdesivir, chloroquine, hydroxychloroquine, and immunosuppressant drugs have all been shown to help to fight the virus.Until a treatment for the COVID-19 virus is found, it is best to stay away from other people and follow strict hygiene.Most medicinal treatments still have a lot of unknown effects, and different medicines and vaccines are being trialed and tested succefully to stop prevelance, transmission and develop the symptoms.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.794
Threshold uncertainty score0.596

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.002
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.041
GPT teacher head0.355
Teacher spread0.314 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

Explore more

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